Anaesthesia / ICU Neurology B
Phenytoin Correction for Albumin / Renal Failure
Corrects total phenytoin level for hypoalbuminaemia and/or renal failure to estimate free (active) phenytoin concentration. Therapeutic range for free phenytoin: 1–2 mg/L.
References
- Winter ME. Basic Clinical Pharmacokinetics. 5th ed. Lippincott Williams & Wilkins; 2009.
- Tozer TN, Winter ME. Phenytoin. In: Applied Pharmacokinetics: Principles of Therapeutic Drug Monitoring. 3rd ed. 1992.
Related
Curated clinical cross-links plus same-class fallbacks.
Calculators
Drugs
- Fosphenytoin sodium · Phenytoin prodrug (anticonvulsant)
- Vancomycin (Renal Dosing) · Antibiotic Dosing in CKD
- Gentamicin (Renal Dosing/TDM) · Antibiotic Dosing in CKD
- Mannitol (Osmotic Diuretic — Renal/Neurological) · Acute Oliguric Renal Failure / Raised ICP
- Phenylephrine · Alpha-1 Adrenergic Agonist (Pure Vasoconstrictor)
- Hydrocortisone (ICU — Stress Dosing) · Corticosteroid (ICU/Septic Shock)
Pathways
- Acute Stroke / TIA Assessment · NICE NG128; RCP Stroke Guidelines 2023
- Status Epilepticus (Adults) · NICE CG137; ESEM guidelines; RCP Neurology Guidelines
- Acute Stroke Management · NICE NG128 / RCP 2023
- TIA Assessment (ABCD2) · NICE NG128 / NICE CG68
- Bacterial Meningitis (Adults) · NICE CG102 / BIA 2016
- Parkinson's Disease Management · NICE NG71 2017
Decision support only — verify against MDCalc, NICE, or your local guideline before clinical use.