Recombinant interleukin-2
Aldesleukin [Specialist drug]
Brand names: Proleukin
Adult dose
Dose: Specialist; SC or IV per protocol
Route: SC/IV
Frequency: Per SACT/SmPC
Clinical pearls
- Metastatic RCC/melanoma in selected centres; defer dosing to BNF/SmPC
Contraindications
- Significant cardiac/pulmonary/renal/hepatic dysfunction
- Active infection
Side effects
- Capillary leak syndrome
- Hypotension
- Arrhythmias
- Pulmonary oedema
Interactions
- Nephrotoxins
- Corticosteroids reduce efficacy
Monitoring
- BP, weight, U&E
- ICU support if high-dose
Reference: BNF; ESMO; SmPC Proleukin. Verify against your local formulary and the latest BNF before prescribing.
Related
Curated clinical cross-links plus same-class fallbacks.
Calculators
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