Topical alkylating agent
Chlormethine (Specialist drug)
Brand names: Ledaga
Adult dose
Dose: Specialist initiation only — refer to BNF/SmPC
Route: Topical
Frequency: OD
Clinical pearls
- Stage IA–IB mycosis fungoides cutaneous T-cell lymphoma; gloves required for application
Contraindications
- Hypersensitivity
Side effects
- Dermatitis
- Pruritus
- Skin hyperpigmentation
- Secondary skin malignancy
Reference: BNF; https://bnf.nice.org.uk/drugs/chlormethine-specialist-drug/. Verify against your local formulary and the latest BNF before prescribing.
Related
Curated clinical cross-links plus same-class fallbacks.
Calculators
- Vancomycin Dosing Calculator · Drug Dosing
- Phenytoin Correction for Albumin / Renal Failure · Drug Dosing
- Local Anaesthetic Maximum Dose Calculator · Drug Dosing
- Tisdale Risk Score for QT Prolongation · Arrhythmia
- Bazett Corrected QT Interval (QTc) Calculator · Arrhythmia
- DAPT Score for Dual Antiplatelet Therapy Duration · Antiplatelet Therapy
Pathways
- Acute Myeloid Leukaemia Presentation · BSH; NICE — NG146
- Tumour Lysis Syndrome · Cairo-Bishop; BSH; NICE — Best Practice
- Suspicious Pigmented Lesion — Melanoma Pathway · NICE NG14 2015 / BAD
- Cellulitis and Erysipelas · NICE NG141 2019 / CREST
- Psoriasis — Severity Assessment and Step-Up Therapy · NICE NG153 2019 / BAD
- Atopic Eczema — Assessment and Step-Up Therapy · NICE NG95 2023