MEK inhibitor
Cobimetinib (Specialist drug)
Brand names: Cotellic
Adult dose
Dose: Specialist initiation only — refer to BNF/SmPC
Route: PO
Frequency: OD
Clinical pearls
- Combined with vemurafenib for BRAF V600 metastatic melanoma; specialist oncology only
Contraindications
- See SmPC
Side effects
- Diarrhoea
- Photosensitivity
- Cardiomyopathy
- Retinopathy
- Hepatotoxicity
- CK elevation
- Haemorrhage
Interactions
- Strong CYP3A4 inhibitors/inducers
Monitoring
- LFTs
- CK
- Echo (LVEF)
- Ophthalmic exam
Reference: BNF; https://bnf.nice.org.uk/drugs/cobimetinib-specialist-drug/. Verify against your local formulary and the latest BNF before prescribing.
Related
Curated clinical cross-links plus same-class fallbacks.
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