ALK/ROS1 tyrosine-kinase inhibitor
Crizotinib (Specialist drug)
Brand names: Xalkori
Adult dose
Dose: Specialist initiation only — refer to BNF/SmPC
Route: PO
Frequency: BD
Clinical pearls
- ALK- or ROS1-positive NSCLC; specialist oncology only
Contraindications
- See SmPC
Side effects
- Visual disturbance
- GI toxicity
- Hepatotoxicity
- QT prolongation
- ILD
- Bradycardia
Interactions
- Strong CYP3A4 inhibitors/inducers
- QT-prolonging drugs
Monitoring
- LFTs
- ECG
- Visual exam
Reference: BNF; https://bnf.nice.org.uk/drugs/crizotinib-specialist-drug/. Verify against your local formulary and the latest BNF before prescribing.
Related
Curated clinical cross-links plus same-class fallbacks.
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