FGFR1-4 tyrosine-kinase inhibitor
Futibatinib (Specialist drug)
Brand names: Lytgobi
Adult dose
Dose: Specialist initiation only — refer to BNF/SmPC
Route: PO
Frequency: OD
Clinical pearls
- FGFR2 fusion-positive intrahepatic cholangiocarcinoma; specialist oncology
Contraindications
- See SmPC
Side effects
- Hyperphosphataemia
- Nail/hair changes
- Stomatitis
- Diarrhoea
- Retinal pigment epithelial detachment
- Hepatotoxicity
Interactions
- Strong CYP3A4 inhibitors/inducers
- P-gp substrates
Monitoring
- Phosphate
- Ophthalmic exam
- LFTs
Reference: BNF; NICE TA936; SmPC; https://bnf.nice.org.uk/drugs/futibatinib-specialist-drug/. Verify against your local formulary and the latest BNF before prescribing.
Related
Curated clinical cross-links plus same-class fallbacks.
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