TRK tyrosine-kinase inhibitor
Larotrectinib (Specialist drug)
Brand names: Vitrakvi
Adult dose
Dose: Specialist initiation only — refer to BNF/SmPC
Route: PO
Frequency: BD
Clinical pearls
- NTRK-fusion-positive solid tumours (tumour-agnostic indication); specialist oncology
Contraindications
- See SmPC
Side effects
- Hepatotoxicity
- Neurotoxicity (dizziness, ataxia, paraesthesia)
- Skeletal fractures (children)
- Anaemia
Interactions
- Strong CYP3A4 modulators
- P-gp substrates
Monitoring
- LFTs
- Neurological exam
Reference: BNF; NICE TA630; SmPC; https://bnf.nice.org.uk/drugs/larotrectinib-specialist-drug/. Verify against your local formulary and the latest BNF before prescribing.
Related
Curated clinical cross-links plus same-class fallbacks.
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