Macrophage activator (MTP-PE)
Mifamurtide (Specialist drug)
Brand names: Mepact
Adult dose
Dose: Specialist initiation only — refer to BNF/SmPC
Route: IV infusion
Frequency: per protocol
Clinical pearls
- High-grade non-metastatic resectable osteosarcoma after surgery (≤30y)
- Specialist sarcoma centre
Contraindications
- Hypersensitivity
- Concurrent corticosteroids
- Concurrent NSAIDs (high dose)
Side effects
- Fever
- Chills
- Hypotension
- Hypersensitivity
- Tachycardia
- Dyspnoea
Interactions
- Corticosteroids reduce efficacy
Monitoring
- BP
- Vital signs during infusion
Reference: BNF; NICE TA235; SmPC; https://bnf.nice.org.uk/drugs/mifamurtide-specialist-drug/. Verify against your local formulary and the latest BNF before prescribing.
Related
Curated clinical cross-links plus same-class fallbacks.
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