Anti-HER2 monoclonal antibody (dimerisation inhibitor)
Pertuzumab (Specialist drug)
Brand names: Perjeta
Adult dose
Dose: Specialist initiation only — refer to BNF/SmPC
Route: IV
Frequency: every 3 weeks
Clinical pearls
- HER2-positive breast cancer with trastuzumab + chemotherapy
- Specialist oncology
Contraindications
- Severe hypersensitivity
- Severe LV dysfunction
- Pregnancy
Side effects
- Cardiotoxicity (LV dysfunction)
- Diarrhoea
- Infusion reactions
- Rash
- Mucositis
Interactions
- Anthracyclines (cardiac additive)
- Live vaccines
Monitoring
- LVEF (echo)
- FBC
Reference: BNF; NICE TA424/TA569; SmPC; https://bnf.nice.org.uk/drugs/pertuzumab-specialist-drug/. Verify against your local formulary and the latest BNF before prescribing.
Related
Curated clinical cross-links plus same-class fallbacks.
Calculators
- Vancomycin Dosing Calculator · Drug Dosing
- Phenytoin Correction for Albumin / Renal Failure · Drug Dosing
- Local Anaesthetic Maximum Dose Calculator · Drug Dosing
- Tisdale Risk Score for QT Prolongation · Arrhythmia
- Bazett Corrected QT Interval (QTc) Calculator · Arrhythmia
- DAPT Score for Dual Antiplatelet Therapy Duration · Antiplatelet Therapy