Thymidylate synthase inhibitor
Raltitrexed (Specialist drug)
Brand names: Tomudex
Adult dose
Dose: Specialist initiation only — refer to BNF/SmPC
Route: IV
Frequency: every 3 weeks
Clinical pearls
- Advanced colorectal cancer when 5-FU/folinic acid not tolerated
- Specialist oncology
Contraindications
- Severe renal/hepatic impairment
- Severe myelosuppression
- Pregnancy
Side effects
- Myelosuppression
- GI toxicity
- Hepatotoxicity
- Asthenia
Interactions
- Folate antagonists
- Live vaccines
Monitoring
- FBC
- LFTs
- Renal function
Reference: BNF; SmPC; https://bnf.nice.org.uk/drugs/raltitrexed-specialist-drug/. Verify against your local formulary and the latest BNF before prescribing.
Related
Curated clinical cross-links plus same-class fallbacks.
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