KRAS G12C inhibitor
Sotorasib (Specialist drug)
Brand names: Lumykras
Adult dose
Dose: Specialist initiation only — refer to BNF/SmPC
Route: PO
Frequency: OD
Clinical pearls
- KRAS G12C-mutated metastatic NSCLC after prior systemic therapy
- Specialist oncology
Contraindications
- Hypersensitivity
- Severe hepatic impairment
Side effects
- Hepatotoxicity
- ILD/pneumonitis
- Diarrhoea
- Nausea
- Fatigue
- QT prolongation
Interactions
- Acid-reducing agents (avoid PPIs/H2)
- Strong CYP3A4 inducers
Monitoring
- LFTs
- Pulmonary symptoms
Reference: BNF; NICE TA781; SmPC; https://bnf.nice.org.uk/drugs/sotorasib-specialist-drug/. Verify against your local formulary and the latest BNF before prescribing.
Related
Curated clinical cross-links plus same-class fallbacks.
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