Nitrosourea cytotoxic
Streptozocin (Specialist drug)
Brand names: Zanosar
Adult dose
Dose: Specialist initiation only — refer to BNF/SmPC
Route: IV
Frequency: per protocol
Clinical pearls
- Pancreatic islet-cell tumours
- Specialist oncology — strict renal monitoring
Contraindications
- Severe renal impairment
- Pregnancy
- Hypersensitivity
Side effects
- Severe nephrotoxicity (dose-limiting — black box)
- Nausea/vomiting
- Hepatotoxicity
- Hypoglycaemia / hyperglycaemia
- Myelosuppression
Interactions
- Nephrotoxic drugs
- Live vaccines
Monitoring
- Renal function
- LFTs
- Glucose
- FBC
Reference: BNF; SmPC; https://bnf.nice.org.uk/drugs/streptozocin-specialist-drug/. Verify against your local formulary and the latest BNF before prescribing.
Related
Curated clinical cross-links plus same-class fallbacks.
Calculators
- Vancomycin Dosing Calculator · Drug Dosing
- Phenytoin Correction for Albumin / Renal Failure · Drug Dosing
- Local Anaesthetic Maximum Dose Calculator · Drug Dosing
- Tisdale Risk Score for QT Prolongation · Arrhythmia
- Bazett Corrected QT Interval (QTc) Calculator · Arrhythmia
- DAPT Score for Dual Antiplatelet Therapy Duration · Antiplatelet Therapy
Pathways
- Acute Myeloid Leukaemia Presentation · BSH; NICE — NG146
- Tumour Lysis Syndrome · Cairo-Bishop; BSH; NICE — Best Practice
- Diabetic Ketoacidosis (DKA) · JBDS 2013 / Joint British Diabetes Societies; NICE NG17
- Adult Hypoglycaemia (Treated Diabetes) · JBDS-IP (2023): Hospital Management of Hypoglycaemia
- Adrenal Crisis · Society for Endocrinology Emergency Guidance (2024)
- Type 2 Diabetes Management · NICE NG28 2022