Bispecific DLL3 × CD3 T-cell engager
Tarlatamab (Specialist drug)
Brand names: Imdelltra
Adult dose
Dose: Specialist initiation only — refer to BNF/SmPC
Route: IV
Frequency: every 2 weeks
Clinical pearls
- Extensive-stage SCLC after platinum chemotherapy
- Specialist oncology; CRS/ICANS monitoring
Contraindications
- Active serious infection
- Pregnancy
- Hypersensitivity
Side effects
- CRS (boxed)
- ICANS
- Cytopenias
- Infections
- Hepatotoxicity
Interactions
- Live vaccines
- CYP substrates
Monitoring
- Vitals
- Neuro
- FBC
- LFTs
Reference: BNF; SmPC; https://bnf.nice.org.uk/drugs/tarlatamab-specialist-drug/. Verify against your local formulary and the latest BNF before prescribing.
Related
Curated clinical cross-links plus same-class fallbacks.
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