Bispecific gp100 × CD3 (ImmTAC)
Tebentafusp (Specialist drug)
Brand names: Kimmtrak
Adult dose
Dose: Specialist initiation only — refer to BNF/SmPC
Route: IV
Frequency: weekly
Clinical pearls
- HLA-A*02:01-positive metastatic uveal melanoma
- Specialist oncology — first 3 doses inpatient
Contraindications
- HLA-A*02:01 negative
- Active infection
- Pregnancy
- Hypersensitivity
Side effects
- CRS
- Skin reactions (rash, pruritus)
- Hypotension
- Pyrexia
- Hepatic enzyme elevation
Interactions
- Live vaccines
Monitoring
- Vitals
- LFTs
- Skin
Reference: BNF; NICE TA864; SmPC; https://bnf.nice.org.uk/drugs/tebentafusp-specialist-drug/. Verify against your local formulary and the latest BNF before prescribing.
Related
Curated clinical cross-links plus same-class fallbacks.
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