Selective MET kinase inhibitor
Tepotinib (Specialist drug)
Brand names: Tepmetko
Adult dose
Dose: Specialist initiation only — refer to BNF/SmPC
Route: PO
Frequency: OD
Clinical pearls
- MET exon 14 skipping NSCLC
- Specialist oncology
Contraindications
- Severe hepatic impairment
- Hypersensitivity
Side effects
- Peripheral oedema
- Hypoalbuminaemia
- ILD/pneumonitis
- Hepatotoxicity
- Increased creatinine
Interactions
- P-gp/BCRP substrates
- Acid-reducing agents
Monitoring
- LFTs
- Pulmonary symptoms
- Albumin
Reference: BNF; NICE TA789; SmPC; https://bnf.nice.org.uk/drugs/tepotinib-specialist-drug/. Verify against your local formulary and the latest BNF before prescribing.
Related
Curated clinical cross-links plus same-class fallbacks.
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