VEGFR tyrosine-kinase inhibitor
Tivozanib (Specialist drug)
Brand names: Fotivda
Adult dose
Dose: Specialist initiation only — refer to BNF/SmPC
Route: PO
Frequency: OD x 21 days q28
Clinical pearls
- Advanced RCC (1st-line)
- Specialist oncology
Contraindications
- Severe hypertension
- Recent thromboembolism
- Pregnancy
- Hypersensitivity
Side effects
- Hypertension
- Diarrhoea
- Asthenia
- Hand-foot syndrome
- Bleeding
- Proteinuria
- QT prolongation
Interactions
- Strong CYP3A4 modulators
- Anticoagulants
- QT-prolonging drugs
Monitoring
- BP
- Urinalysis
- ECG
- TFTs
Reference: BNF; NICE TA512; SmPC; https://bnf.nice.org.uk/drugs/tivozanib-specialist-drug/. Verify against your local formulary and the latest BNF before prescribing.
Related
Curated clinical cross-links plus same-class fallbacks.
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