Marine-derived alkylating cytotoxic
Trabectedin (Specialist drug)
Brand names: Yondelis
Adult dose
Dose: Specialist initiation only — refer to BNF/SmPC
Route: IV
Frequency: every 3 weeks
Clinical pearls
- Advanced soft-tissue sarcoma; relapsed platinum-sensitive ovarian cancer
- Specialist oncology — central line preferred
Contraindications
- Severe hepatic impairment
- Severe myelosuppression
- Pregnancy
- Hypersensitivity
Side effects
- Severe myelosuppression
- Hepatotoxicity
- Rhabdomyolysis
- Cardiotoxicity
- Capillary leak (rare)
Interactions
- Strong CYP3A4 modulators
- Live vaccines
Monitoring
- FBC
- LFTs
- CK
- Cardiac
Reference: BNF; NICE TA185/TA389; SmPC; https://bnf.nice.org.uk/drugs/trabectedin-specialist-drug/. Verify against your local formulary and the latest BNF before prescribing.
Related
Curated clinical cross-links plus same-class fallbacks.
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