Anti-HER2 monoclonal antibody
Trastuzumab (Specialist drug)
Brand names: Herceptin, Herzuma, Ontruzant
Adult dose
Dose: Specialist initiation only — refer to BNF/SmPC
Route: IV/SC
Frequency: every 3 weeks
Clinical pearls
- HER2-positive breast and gastric cancer
- Specialist oncology — baseline + serial echo
Contraindications
- Severe LV dysfunction
- Severe hypersensitivity
- Pregnancy
Side effects
- Cardiotoxicity (LV dysfunction)
- Infusion reactions
- Pulmonary toxicity
- Diarrhoea
- Cytopenias
Interactions
- Anthracyclines (cardiac additive)
- Live vaccines
Monitoring
- LVEF
- FBC
- Pulmonary symptoms
Reference: BNF; NICE TA34/TA208; SmPC; https://bnf.nice.org.uk/drugs/trastuzumab-specialist-drug/. Verify against your local formulary and the latest BNF before prescribing.
Related
Curated clinical cross-links plus same-class fallbacks.
Calculators
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