Anti-CTLA-4 monoclonal antibody
Tremelimumab (Specialist drug)
Brand names: Imjudo
Adult dose
Dose: Specialist initiation only — refer to BNF/SmPC
Route: IV
Frequency: per protocol
Clinical pearls
- Hepatocellular carcinoma (with durvalumab); NSCLC
- Specialist oncology
Contraindications
- Active autoimmune disease
- Severe hepatic impairment
- Pregnancy
- Hypersensitivity
Side effects
- Immune-mediated AEs (colitis, hepatitis, pneumonitis, endocrinopathies)
- Infusion reactions
- Severe skin reactions
Interactions
- Live vaccines
- Systemic corticosteroids
Monitoring
- TFTs
- LFTs
- Cortisol
- Symptoms
Reference: BNF; NICE TA887; SmPC; https://bnf.nice.org.uk/drugs/tremelimumab-specialist-drug/. Verify against your local formulary and the latest BNF before prescribing.
Related
Curated clinical cross-links plus same-class fallbacks.
Calculators
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