HER2 selective tyrosine-kinase inhibitor
Tucatinib (Specialist drug)
Brand names: Tukysa
Adult dose
Dose: Specialist initiation only — refer to BNF/SmPC
Route: PO
Frequency: BD
Clinical pearls
- HER2+ advanced breast cancer (with trastuzumab + capecitabine), especially CNS metastases
- Specialist oncology
Contraindications
- Severe hepatic impairment
- Hypersensitivity
Side effects
- Diarrhoea
- Hepatotoxicity
- Palmar-plantar erythrodysaesthesia
- Nausea
- Cytopenias
Interactions
- Strong CYP3A4 modulators
- CYP2C8 inhibitors
Monitoring
- LFTs
- FBC
Reference: BNF; NICE TA731; SmPC; https://bnf.nice.org.uk/drugs/tucatinib-specialist-drug/. Verify against your local formulary and the latest BNF before prescribing.
Related
Curated clinical cross-links plus same-class fallbacks.
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