BRAF V600 inhibitor
Vemurafenib (Specialist drug)
Brand names: Zelboraf
Adult dose
Dose: Specialist initiation only — refer to BNF/SmPC
Route: PO
Frequency: BD
Clinical pearls
- BRAF V600 mutated melanoma; usually combined with MEK inhibitor
- Specialist oncology
Contraindications
- Hypersensitivity
- Severe hepatic impairment
Side effects
- Cutaneous SCC / new primary melanoma
- Severe skin reactions (SJS/TEN, DRESS)
- QT prolongation
- Hepatotoxicity
- Photosensitivity
- Uveitis
Interactions
- Strong CYP3A4 modulators
- QT-prolonging drugs
Monitoring
- ECG
- LFTs
- Skin
- Eye
Reference: BNF; NICE TA269; SmPC; https://bnf.nice.org.uk/drugs/vemurafenib-specialist-drug/. Verify against your local formulary and the latest BNF before prescribing.
Related
Curated clinical cross-links plus same-class fallbacks.
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