α-blocker + 5α-reductase inhibitor
Tamsulosin with dutasteride
Brand names: Combodart
Adult dose
Dose: 400 micrograms / 500 micrograms PO OD
Route: PO
Frequency: OD
Clinical pearls
- Moderate-severe BPH with prostate enlargement
- Halves PSA — adjust interpretation
Contraindications
- Pregnancy (handling)
- Severe hepatic impairment
- Hypersensitivity
Side effects
- Postural hypotension
- Sexual dysfunction
- Gynaecomastia
- IFIS
- Reduced PSA (~50%)
Interactions
- Strong CYP3A4 modulators
- Other α-blockers
- PDE5 inhibitors
Monitoring
- PSA (adjusted)
- BP
Reference: BNF; NICE NG106; https://bnf.nice.org.uk/drugs/tamsulosin-with-dutasteride/. Verify against your local formulary and the latest BNF before prescribing.
Related
Curated clinical cross-links plus same-class fallbacks.
Calculators
- SMART Risk Score for Recurrent CVD · Cardiovascular Risk
- MAGGIC Heart Failure Risk Score · Heart Failure
- Long QT Syndrome (Schwartz Score) · Channelopathy / Sudden Cardiac Death
- PCSK9 Inhibitor Eligibility Assessment · Lipid Management
- Immune-Related Adverse Events (irAE) -- GI Toxicity Colitis Grading · Oncology-Related GI
- irAE Hepatitis Grading (CTCAE) · Immunotherapy