α-blocker + antimuscarinic
Tamsulosin with solifenacin
Brand names: Vesomni
Adult dose
Dose: 400 micrograms / 6mg PO OD
Route: PO
Frequency: OD
Clinical pearls
- BPH with persistent storage symptoms despite tamsulosin alone
- Combination simplifies regimen
Contraindications
- Urinary retention
- GI obstruction
- Glaucoma
- Myasthenia
- Severe hepatic impairment
Side effects
- Dry mouth
- Constipation
- Postural hypotension
- IFIS
- Anticholinergic burden
Interactions
- Strong CYP3A4 inhibitors
- Other antimuscarinics
- α-blockers
Monitoring
- PVR
- Symptoms
Reference: BNF; NICE NG106; https://bnf.nice.org.uk/drugs/tamsulosin-with-solifenacin/. Verify against your local formulary and the latest BNF before prescribing.
Related
Curated clinical cross-links plus same-class fallbacks.
Calculators