β3-adrenergic agonist
Vibegron
Brand names: Obgemsa
Adult dose
Dose: 75mg PO OD
Route: PO
Frequency: OD
Clinical pearls
- Overactive bladder — alternative to mirabegron
- Less drug-interaction profile
Contraindications
- Severe uncontrolled hypertension
- End-stage renal disease
- Severe hepatic impairment
- Hypersensitivity
Side effects
- Hypertension
- Headache
- UTI
- Constipation
- Urinary retention
Interactions
- Digoxin (monitor levels)
- P-gp substrates
Monitoring
- BP
- Symptoms
Reference: BNF; SmPC; https://bnf.nice.org.uk/drugs/vibegron/. Verify against your local formulary and the latest BNF before prescribing.
Related
Curated clinical cross-links plus same-class fallbacks.