General MedicineGeriatrics
Delirium Outside ICU
Acute confusional state; identify cause (TIME-IT mnemonic); non-pharmacological first; pharmacological last resort.
Source: NICE CG103
Step 1 of ~3
info
Recognise Delirium
Acute fluctuating disturbance of attention + cognition + consciousness.
Two main subtypes:
• Hyperactive: restless, agitated, hallucinations, delusions, wandering.
• Hypoactive: drowsy, withdrawn, slow responses (often missed — worse prognosis).
• Mixed.
SCREEN with 4AT (Alertness, AMT4 — age / DOB / place / current year, Attention — months backwards, Acute Change / Fluctuating Course):
• Score 0: delirium unlikely.
• Score 1–3: cognitive impairment.
• Score ≥4: possible delirium + cognitive impairment.
CAM (Confusion Assessment Method) alternative.
Distinguish from dementia: delirium is acute (hours-days); dementia is gradual (months-years). Delirium can be superimposed on dementia.
Related
Curated clinical cross-links plus same-class fallbacks.
Drugs
- Colistin (Polymyxin E) · Polymyxin — Last-Resort MDR / Carbapenem-Resistant Gram-Negatives
- Colistin (Polymyxin E — XDR Burns Infection) · Antibiotic — Polymyxin (Last-Resort)
- Glyceryl Trinitrate (Sublingual / IV) · Nitrate / Acute Angina
- Dobutamine (Acute HF / Stress Echo) · Inotrope / Acute Heart Failure
- Milrinone · Inodilator / Acute Heart Failure
- Prednisolone (Systemic) · Systemic Corticosteroid — Acute Dermatoses
Pathways
- Sepsis Screening and Sepsis Six · UK Sepsis Trust; NICE NG51; Surviving Sepsis Campaign 2021
- Unintentional Weight Loss Workup · NICE NG12; BSG
- Chronic Fatigue Workup · NICE NG206; BMJ Best Practice
- Lymphadenopathy Workup · NICE NG12; BMJ Best Practice
- Pre-op Medical Clearance · NICE NG45; ESC 2022
- Secondary Hypertension Workup · NICE NG136; ESH 2023
Decision support only. Always apply local guidelines and clinical judgement.