endocrinology

Acromegaly Diagnosis Score (SAGIT)

Acromegaly is confirmed by IGF-I above 1.3 × the age-adjusted upper limit with typical features (Acromegaly Consensus Conference, Pituitary 2024). SAGIT® (signs and symptoms, associated comorbidities, GH, IGF-I, tumour) is a clinician staging form with its own scoring — not the 5-item tally this page used.

Result

SAGIT® (Giustina, Pituitary 2016) is a clinician staging form scored on its own grid (signs and symptoms 0–4, associated comorbidities 0–6, GH 0–4, IGF-I 0–3, tumour 0–5); its validation (J Clin Endocrinol Metab 2021) set no single total cut-off, and the 5-item tally this page used was not SAGIT. Acromegaly Consensus 2024: with typical features, IGF-I above 1.3 × the age-adjusted upper limit confirms the diagnosis (oral glucose tolerance test if equivocal); remission is a normal IGF-I, first checked 12 weeks after surgery. Follow up with IGF-I, MRI for residual or recurrent adenoma, and the clinical features and comorbidities; refer to a pituitary multidisciplinary team.

References

Curated clinical cross-links plus same-class fallbacks.

Drugs

Pathways

Decision support only — verify against a current formulary, NICE, or your local guideline before clinical use.

References

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