HOMA-IR — Insulin Resistance
Homeostatic Model Assessment of Insulin Resistance. HOMA-IR = (Fasting Glucose × Fasting Insulin) / 22.5.
Score interpretation
HOMA-IR <1.0: Good insulin sensitivity
→ Normal; lifestyle maintenance advised
HOMA-IR 1.0–1.9: Within normal population range
→ Monitor annually; promote exercise and healthy diet
HOMA-IR 2.0–2.9: Early insulin resistance
→ Lifestyle modification; weight management; fasting glucose/HbA1c; consider lipid profile
HOMA-IR ≥3.0: Significant insulin resistance
→ Diabetes/metabolic syndrome workup; consider metformin in high-risk; endocrinology referral
Interpretation bands for the HOMA-IR. Apply clinical judgement and local guidance.
References
- Matthews DR, et al. Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations. Diabetologia. 1985;28(7):412-419.
Related
Curated clinical cross-links plus same-class fallbacks.
- Insulin (IV Infusion — ICU Glucose Control) · Insulin — ICU Glucose Management
- Trimetazidine · Metabolic Anti-Anginal
- L-Carnitine · Antidote / Metabolic Agent
- Insulin (Soluble / Actrapid) · Insulin
- Insulin Glargine · Long-Acting Insulin Analogue (Basal)
- Insulin Aspart · Rapid-Acting Insulin Analogue (Bolus)
- Diabetic Ketoacidosis (DKA) · JBDS 2013 / Joint British Diabetes Societies; NICE NG17
- Adult Hypoglycaemia (Treated Diabetes) · JBDS-IP (2023): Hospital Management of Hypoglycaemia
- Adrenal Crisis · Society for Endocrinology Emergency Guidance (2024)
- Type 2 Diabetes Management · NICE NG28 2022
- Hyperthyroidism Management · BTA / ETA 2018
- Adrenal Insufficiency · Society of Endocrinology / ESE 2016
Decision support only — verify against a current formulary, NICE, or your local guideline before clinical use.