endocrinology

Pheochromocytoma Clinical Probability (10% Rule)

Guidance on whom to test for phaeochromocytoma and paraganglioma (PPGL). There is no validated points score — the page's tally (and its "10% rule" name) was not a published method.

Result

There is no validated points score for phaeochromocytoma or paraganglioma (PPGL). Endocrine Society 2014: test with plasma free metanephrines or urinary fractionated metanephrines in people with signs and symptoms of PPGL (especially paroxysmal headache, sweating, palpitations or hypertension), symptoms provoked by drugs (e.g. dopamine D2 antagonists, beta-blockers, sympathomimetics, opioids, noradrenaline or serotonin reuptake inhibitors, MAO inhibitors), an adrenal incidentaloma with or without hypertension, a hereditary predisposition or syndromic features (e.g. MEN2, VHL, NF1, SDHx), or a history of PPGL. Positive results need imaging and specialist referral; alpha-blockade comes before any beta-blockade.

References

Curated clinical cross-links plus same-class fallbacks.

Calculators

Drugs

Pathways

Decision support only — verify against a current formulary, NICE, or your local guideline before clinical use.

References

Related