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endocrinology general-medicine

Thyroid Function Test Interpretation

Systematically interprets TSH + free T4 patterns to identify hypothyroid, hyperthyroid, subclinical, and central thyroid disease. Guides management decisions.

Used in: Thyroid Disorders

Score interpretation

Normal thyroid function or subclinical hypothyroidism (low risk)

→ Normal TFTs: no action; subclinical hypothyroid (TSH 4-10, normal T4): recheck in 3-6 months; treat if TSH >10 or symptomatic; screen for autoimmune cause (TPO antibodies)

Overt hypothyroidism or subclinical hyperthyroid

→ Hypothyroid: levothyroxine 1.6mcg/kg/day (start 25-50mcg in elderly/cardiac); recheck TSH in 6-8 weeks; titrate to TSH 0.4-2.0; subclinical hyperthyroid: bone and cardiac risk assessment; refer if TSH <0.1 persistently

Overt hyperthyroidism or central thyroid disease

→ Overt hyperthyroid (low TSH + high T4): endocrinology; carbimazole 20-40mg daily; propranolol for symptoms; thyroid scan (isotope); definitive: radioiodine or thyroidectomy; central hypothyroid (low TSH + low T4): MRI pituitary; cortisol before levothyroxine (avoid adrenal crisis)

Interpretation bands for the TFT Interpretation. Apply clinical judgement and local guidance.

References

Related

Curated clinical cross-links plus same-class fallbacks.

Decision support only — verify against a current formulary, NICE, or your local guideline before clinical use.