CLIF-C ACLF Score
Chronic Liver Failure Consortium — ACLF score predicts 28-day and 90-day mortality in acute-on-chronic liver failure (ACLF). Based on organ failure count, age, WBC, and creatinine.
Score interpretation
Lower 28-day mortality risk with ACLF
→ Intensive medical management; reassess daily; transplant evaluation
Intermediate 28-day mortality risk (~30–50%)
→ HDU/ICU care; urgent transplant evaluation; address precipitating factors
High 28-day mortality risk (>50–75%)
→ ICU care; urgent liver transplant if candidate; goals-of-care discussion with patient/family
Interpretation bands for the CLIF-C ACLF. Apply clinical judgement and local guidance.
References
- Jalan R et al. Development and validation of a prognostic score to predict mortality in patients with acute-on-chronic liver failure. J Hepatol. 2014;61(5):1038–1047.
Related
Curated clinical cross-links plus same-class fallbacks.
- Dobutamine (Acute HF / Stress Echo) · Inotrope / Acute Heart Failure
- Milrinone · Inodilator / Acute Heart Failure
- Mannitol (Osmotic Diuretic — Renal/Neurological) · Acute Oliguric Renal Failure / Raised ICP
- Glyceryl Trinitrate (Sublingual / IV) · Nitrate / Acute Angina
- Vericiguat · Heart Failure
- Ferric Carboxymaltose · Heart Failure
Decision support only — verify against a current formulary, NICE, or your local guideline before clinical use.