CLIF-C ACLF Score
Chronic Liver Failure Consortium — ACLF score predicts 28-day and 90-day mortality in acute-on-chronic liver failure (ACLF). Based on organ failure count, age, WBC, and creatinine.
Score interpretation
CLIF-C ACLF < 45: 28-day mortality below about 20 %.
→ Hepatology-led care; treat precipitants; assess transplant candidacy.
CLIF-C ACLF 45–64: 28-day mortality between about 20 % and 80 %.
→ Critical-care and transplant-centre discussion; reassess the score at 48 h.
CLIF-C ACLF ≥ 65: 28-day mortality above about 80 %; ≥ 70 after 48 h of ICU care has been associated with futility.
→ Senior multidisciplinary review of goals of care and transplant options.
Interpretation bands for the CLIF-C ACLF. Apply clinical judgement and local guidance.
References
- Jalan R et al. Development and validation of a prognostic score to predict mortality in patients with acute-on-chronic liver failure. J Hepatol. 2014;61(5):1038–1047.
Related
Curated clinical cross-links plus same-class fallbacks.
- Dobutamine (Acute HF / Stress Echo) · Inotrope / Acute Heart Failure
- Milrinone · Inodilator / Acute Heart Failure
- Mannitol (Osmotic Diuretic — Renal/Neurological) · Acute Oliguric Renal Failure / Raised ICP
- Glyceryl Trinitrate (Sublingual / IV) · Nitrate / Acute Angina
- Vericiguat · Heart Failure
- Ferric Carboxymaltose · Heart Failure
Decision support only — verify against a current formulary, NICE, or your local guideline before clinical use.