haematology general-medicine

Charlson Comorbidity Index (CCI)

Validated index of 19 comorbid conditions, each weighted by their associated 10-year mortality risk. Widely used to predict long-term prognosis and adjust outcomes in clinical research across oncology, surgery, and general medicine.

Myocardial infarction (history of MI, not ECG changes)*

Congestive heart failure (CHF)*

Peripheral vascular disease (claudication, bypass, or amputation)*

Cerebrovascular disease (stroke or TIA without residual deficits)*

Dementia*

Chronic pulmonary disease (COPD, asthma requiring treatment)*

Connective tissue disease (rheumatoid arthritis, SLE, polymyositis)*

Peptic ulcer disease (treated, not just antacids)*

Mild liver disease (hepatitis, without portal hypertension)*

Diabetes without end-organ damage*

Diabetes with end-organ damage (retinopathy, neuropathy, nephropathy)*

Hemiplegia or paraplegia*

Moderate-severe renal disease (creatinine > 265 micromol/L or dialysis)*

Any tumour (solid) -- within last 5 years (not leukaemia or lymphoma)*

Leukaemia (AML, CML, ALL, CLL)*

Lymphoma (including multiple myeloma and Waldenstrom macroglobulinaemia)*

Moderate-severe liver disease (cirrhosis + portal hypertension, variceal bleeding)*

Metastatic solid tumour (including lymph node metastases)*

AIDS (not just HIV positive -- defined AIDS condition)*

References

Charlson ME et al. A new method of classifying prognostic comorbidity in longitudinal studies: development and validation. J Chronic Dis. 1987;40(5):373-383.
Deyo RA et al. Adapting a clinical comorbidity index for use with ICD-9-CM administrative databases. J Clin Epidemiol. 1992;45(6):613-619.

Curated clinical cross-links plus same-class fallbacks.

Calculators

Drugs

Pathways

Decision support only — verify against MDCalc, NICE, or your local guideline before clinical use.

References

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