Clostridioides difficile Severity Grading
Grades C. difficile infection (CDI) severity using ESCMID/IDSA criteria. Guides fidaxomicin vs vancomycin vs bezlotoxumab vs surgery decisions.
Score interpretation
→ Fidaxomicin 200mg BD 10 days (preferred — lower recurrence); or metronidazole 400mg TDS 10 days; stop precipitating antibiotics; contact precautions; daily stool count; test of cure not recommended
→ Oral vancomycin 125mg QDS 10 days; fidaxomicin preferred for recurrence risk; bezlotoxumab 10mg/kg IV single dose if >=2 risk factors for recurrence; surgical review; IV vancomycin enema if ileus
→ Oral + IV vancomycin (500mg QDS) + IV metronidazole 500mg TDS; ICU; surgical team: subtotal colectomy criteria (toxic megacolon, perforation, multi-organ failure); faecal microbiota transplant for recurrent CDI; ID team lead
Interpretation bands for the C. diff Severity. Apply clinical judgement and local guidance.
References
Related
Curated clinical cross-links plus same-class fallbacks.
- Methotrexate (Dermatology — Psoriasis) · Disease-Modifying Antirheumatic / Immunosuppressant
- Activated Charcoal · Gastrointestinal decontamination / Antidote
- Terlipressin · Gastrointestinal Emergency
- Octreotide · Gastrointestinal Emergency
- Acetazolamide (Ménière's Disease) · Carbonic Anhydrase Inhibitor (Diuretic)
- Zinc acetate · Zinc salt (Wilson's disease)
Decision support only — verify against a current formulary, NICE, or your local guideline before clinical use.