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infectious-disease

HIV CD4 Opportunistic Infection Risk

Stratifies risk of AIDS-defining opportunistic infections based on CD4 count. Guides prophylaxis decisions and clinical monitoring.

Score interpretation

Low OI risk (CD4 >500)

→ Standard ART; routine monitoring; no prophylaxis needed

Moderate OI risk (CD4 200-500)

→ Optimise ART adherence; watch for bacterial infections and TB

PCP prophylaxis threshold (CD4 <200)

→ Start co-trimoxazole prophylaxis; screen for TB and toxoplasma

MAC / CMV risk (CD4 <100)

→ Consider MAC prophylaxis (azithromycin); CMV surveillance; intensify monitoring

Critical risk (CD4 <50)

→ High risk CMV, MAC, PCP, cryptococcal meningitis; initiate prophylaxis; urgent ART optimisation

Interpretation bands for the HIV CD4 OI Risk. Apply clinical judgement and local guidance.

References

Related

Curated clinical cross-links plus same-class fallbacks.

Decision support only — verify against a current formulary, NICE, or your local guideline before clinical use.