neonatology infectious-disease

Neonatal Early-Onset Sepsis (EOS) Calculator

Estimates risk of early-onset neonatal sepsis (EOS) using maternal and clinical factors. Based on Kaiser Permanente model.

Result

The Kaiser Permanente early-onset sepsis calculator is a multivariable model: it needs the local incidence of early-onset sepsis, exact gestation, highest intrapartum maternal temperature, hours since rupture of membranes, maternal GBS status, intrapartum antibiotic type and timing, and the baby's clinical condition — use the official online calculator. NICE NG195 allows it for babies born after 34+0 weeks only as part of a prospective audit. Otherwise use the NICE framework: any red flag, or 2 or more other risk factors or clinical indicators — investigate and start antibiotics without waiting for results; 1 risk factor or clinical indicator — use clinical judgement on withholding antibiotics and monitor for at least 12 hours if needed.

References

Puopolo KM, et al. Estimating the probability of neonatal early-onset infection on the basis of maternal risk factors. Pediatrics. 2011;128(5):e1155–e1163.
Kuzniewicz MW, et al. A quantitative, risk-based approach to the management of neonatal early-onset sepsis. JAMA Pediatr. 2017;171(4):365–371.
NICE NG195. Neonatal infection: antibiotics for prevention and treatment. 2021.

Curated clinical cross-links plus same-class fallbacks.

Drugs

Pathways

Decision support only — verify against a current formulary, NICE, or your local guideline before clinical use.

References

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