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neurology

Expanded Disability Status Scale (EDSS)

Quantifies disability in multiple sclerosis and monitors changes over time. Scored 0–10 based on neurological examination across 8 functional systems. Guides treatment decisions and trial eligibility.

Score interpretation

No/Minimal Disability

→ EDSS 0–1.5: No significant disability. Patient is fully ambulatory. Monitor for relapse; continue disease-modifying therapy (DMT) as appropriate.

Mild Disability

→ EDSS 2.0–3.5: Mild disability; fully ambulatory. Review DMT efficacy; physiotherapy; occupational therapy assessment.

Moderate Disability

→ EDSS 4.0–5.5: Moderate disability; ambulatory but impaired. Consider switching to high-efficacy DMT (natalizumab, ocrelizumab); multidisciplinary MS team input; fatigue management.

Walking Aid Required

→ EDSS 6.0–7.5: Walking aid required or restricted to wheelchair. Advanced MS management; symptom management (spasticity, pain, bladder); palliative input for symptom burden.

Severe Disability / Bedridden

→ EDSS 8.0–10: Severely disabled or bedridden. Palliative and supportive care focus; prevent pressure injuries; bladder/bowel care; nutritional support.

Interpretation bands for the EDSS. Apply clinical judgement and local guidance.

References

Related

Curated clinical cross-links plus same-class fallbacks.

Decision support only — verify against a current formulary, NICE, or your local guideline before clinical use.