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Short-acting ester local anaesthetic

Chloroprocaine hydrochloride

Brand names: Ampres, Clorotekal

Adult dose

Dose: Spinal: 30–50mg (1% solution) for surgery up to 40 min. Refer to product
Route: Intrathecal/Epidural/Infiltration
Frequency: per procedure

Clinical pearls

  • Very short duration ideal for short ambulatory surgery (30–40 min)
  • Ester LA — metabolised by plasma cholinesterase

Contraindications

  • Hypersensitivity to ester local anaesthetics
  • Severe cardiac conduction abnormalities
  • Septicaemia

Side effects

  • Hypotension
  • Bradycardia
  • TNS (rare)

Interactions

  • Sulfonamides (PABA metabolite reduces sulfa efficacy)
  • Other LAs (cumulative toxicity)

Reference: BNF; https://bnf.nice.org.uk/drugs/chloroprocaine-hydrochloride/. Verify against your local formulary and the latest BNF before prescribing.

Related

Curated clinical cross-links plus same-class fallbacks.