Bile acid sequestrant
Colesevelam hydrochloride
Brand names: Cholestagel
Adult dose
Dose: 1.875g BD or 3.75g OD with meals; max 4.375g/day
Route: PO
Frequency: OD-BD
Clinical pearls
- Hypercholesterolaemia adjunct, bile-acid diarrhoea; better tolerated than colestyramine
Contraindications
- Bowel obstruction
- Triglycerides >5.6 mmol/L
Side effects
- Constipation
- Flatulence
- Headache
- Hypertriglyceridaemia
Interactions
- Reduces absorption of many drugs — give other drugs at least 4h before colesevelam
- Levothyroxine, warfarin, statins, ciclosporin
Monitoring
- Lipids
- FBG
Reference: BNF; https://bnf.nice.org.uk/drugs/colesevelam-hydrochloride/. Verify against your local formulary and the latest BNF before prescribing.
Related
Curated clinical cross-links plus same-class fallbacks.
Calculators
Pathways
- Acute Heart Failure · ESC 2021 Heart Failure Guidelines; NICE NG106
- NSTEMI / Unstable Angina · ESC 2020 NSTEMI Guidelines; NICE NG185
- New-Onset Atrial Fibrillation · ESC 2020 AF Guidelines; NICE NG196
- Hypertensive Emergency · ESC/ESH 2018 Hypertension Guidelines; NICE NG136
- Bradycardia Management · Resuscitation Council UK ABCDE; ESC 2021 Pacing Guidelines
- Ventricular Tachycardia / Fibrillation · Resuscitation Council UK ACLS; ESC 2022 Ventricular Arrhythmia Guidelines