Angiotensin II receptor antagonist (ARB)
Irbesartan
Brand names: Aprovel
Adult dose
Dose: Initial 150mg OD; max 300mg OD
Route: PO
Frequency: OD
Clinical pearls
- Hypertension, type 2 diabetic nephropathy
Contraindications
- Pregnancy
- Bilateral renal artery stenosis
- Hypersensitivity
Side effects
- Hyperkalaemia
- Renal impairment
- Hypotension
- Dizziness
- Hyperuricaemia
Interactions
- NSAIDs
- Potassium-sparing diuretics
- Lithium
- Sacubitril/valsartan
Monitoring
- U&E
- BP
Reference: BNF; NICE NG136; https://bnf.nice.org.uk/drugs/irbesartan/. Verify against your local formulary and the latest BNF before prescribing.
Related
Curated clinical cross-links plus same-class fallbacks.
Drugs
Pathways
- Acute Heart Failure · ESC 2021 Heart Failure Guidelines; NICE NG106
- NSTEMI / Unstable Angina · ESC 2020 NSTEMI Guidelines; NICE NG185
- New-Onset Atrial Fibrillation · ESC 2020 AF Guidelines; NICE NG196
- Hypertensive Emergency · ESC/ESH 2018 Hypertension Guidelines; NICE NG136
- Bradycardia Management · Resuscitation Council UK ABCDE; ESC 2021 Pacing Guidelines
- Ventricular Tachycardia / Fibrillation · Resuscitation Council UK ACLS; ESC 2022 Ventricular Arrhythmia Guidelines