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Non-selective β-blocker (with intrinsic sympathomimetic activity)

Pindolol

Brand names: Visken

Adult dose

Dose: Hypertension: 5mg BD-TDS, max 45mg/day
Route: PO
Frequency: BD-TDS

Clinical pearls

  • Hypertension where bradycardia from other β-blockers problematic
  • Largely superseded

Contraindications

  • Asthma
  • 2nd/3rd-degree AV block
  • Cardiogenic shock
  • Severe bradycardia
  • Untreated phaeochromocytoma

Side effects

  • Bradycardia (less than other β-blockers — ISA)
  • Bronchospasm
  • Cold extremities
  • Sleep disturbance
  • Fatigue

Interactions

  • Verapamil/diltiazem
  • Other antihypertensives
  • NSAIDs

Monitoring

  • BP
  • HR

Reference: BNF; NICE NG136; https://bnf.nice.org.uk/drugs/pindolol/. Verify against your local formulary and the latest BNF before prescribing.

Related

Curated clinical cross-links plus same-class fallbacks.