Thiazide-like diuretic
Xipamide
Brand names: Diurexan
Adult dose
Dose: Hypertension: 20mg OD in the morning; Oedema: 40mg OD (up to 80mg)
Route: Oral
Frequency: OD
Clinical pearls
- Thiazide-like; long duration of action
- Use in hypertension or oedema when other thiazides ineffective
- Monitor electrolytes, uric acid, glucose
Contraindications
- Refractory hypokalaemia or hyponatraemia
- Hypercalcaemia
- Severe renal or hepatic failure
- Addison's disease
- Hypersensitivity to sulfonamides
Side effects
- Hypokalaemia
- Hyponatraemia
- Hyperglycaemia
- Hyperuricaemia/gout
- Hypotension
- Impotence
Interactions
- Digoxin (hypokalaemia toxicity)
- Lithium (increased levels)
- NSAIDs (reduced effect)
- Antidiabetics (antagonism)
Monitoring
- Electrolytes (K⁺, Na⁺)
- Renal function
- Glucose
- BP
Reference: BNF; https://bnf.nice.org.uk/drugs/xipamide/. Verify against your local formulary and the latest BNF before prescribing.
Related
Curated clinical cross-links plus same-class fallbacks.
Drugs
Pathways
- Acute Heart Failure · ESC 2021 Heart Failure Guidelines; NICE NG106
- NSTEMI / Unstable Angina · ESC 2020 NSTEMI Guidelines; NICE NG185
- New-Onset Atrial Fibrillation · ESC 2020 AF Guidelines; NICE NG196
- Hypertensive Emergency · ESC/ESH 2018 Hypertension Guidelines; NICE NG136
- Bradycardia Management · Resuscitation Council UK ABCDE; ESC 2021 Pacing Guidelines
- Ventricular Tachycardia / Fibrillation · Resuscitation Council UK ACLS; ESC 2022 Ventricular Arrhythmia Guidelines