Clascoterone

How it works

It competes with androgens such as dihydrotestosterone for binding to androgen receptors in the sebaceous gland and hair follicle, reducing sebum production and the inflammation that contribute to acne.

Prescribing in practice

• Local skin reactions and signs suggestive of hypothalamic-pituitary-adrenal axis suppression have been reported, particularly with extensive or prolonged use, so apply only to affected areas as directed.
• It is for topical use only and should not be applied to the eyes, mouth or other mucous membranes.
• Apply to clean, dry skin and avoid use on cut, broken or eczematous skin.

Monitoring

Monitor clinically for treatment response and local irritation; consider HPA-axis effects if used over large areas for prolonged periods.

Counselling the patient

• Apply a thin layer to the affected areas of the face as directed.
• Some local dryness, redness or scaling can occur.
• Use only on the skin and keep it away from the eyes and mouth.

Evidence & guidelines

Clascoterone is a topical anti-androgen licensed for the treatment of acne vulgaris on the basis of its clinical trial programme.