Very potent topical steroid + antibacterial + antifungal
Clobetasol propionate with neomycin and nystatin
Brand names: Dermovate-NN
Adult dose
Dose: Apply thinly OD–BD; max 50g/week; review after 4 weeks
Route: Topical
Frequency: OD-BD
Clinical pearls
- Inflammatory dermatoses with secondary bacterial/fungal infection — short courses only
Contraindications
- As clobetasol; sensitivity to neomycin
Side effects
- As clobetasol; aminoglycoside hypersensitivity
Reference: BNF; https://bnf.nice.org.uk/drugs/clobetasol-propionate-with-neomycin-sulfate-and-nystatin/. Verify against your local formulary and the latest BNF before prescribing.
Related
Curated clinical cross-links plus same-class fallbacks.
Calculators
- Steroid Dose Equivalence · Medications
- Adrenal Crisis Risk Score · Adrenal Disorders
- Lille Model (Steroid Response in Alcoholic Hepatitis) · Alcoholic Liver Disease
- Ho Index for Predicting Response to Medical Therapy in IBD · Inflammatory Bowel Disease
- Steroid Conversion Calculator · Drug Dosing
- FAST Exam Protocol — Focused Assessment with Sonography in Trauma · Trauma
Pathways
- Suspicious Pigmented Lesion — Melanoma Pathway · NICE NG14 2015 / BAD
- Cellulitis and Erysipelas · NICE NG141 2019 / CREST
- Psoriasis — Severity Assessment and Step-Up Therapy · NICE NG153 2019 / BAD
- Atopic Eczema — Assessment and Step-Up Therapy · NICE NG95 2023
- Urticaria and Angioedema · BSACI / EAACI Guidelines 2022
- Acne Vulgaris — Grading and Treatment · NICE NG198 2021 / BAD