Clobetasone butyrate with nystatin and oxytetracycline

Source is the Trimovate Cream SPC (clobetasone butyrate + nystatin + oxytetracycline). Same posology stated for adults, elderly, children and infants. Creams are especially appropriate for moist or weeping surfaces. If the infection worsens, or if the condition does not improve within seven days, treatment and diagnosis should be re-evaluated. Allow adequate time for absorption after each application before applying an emollient. Advise patients to wash their hands after application unless the hands are being treated. Rebound of pre-existing dermatoses can occur with abrupt discontinuation of topical corticosteroids; if further treatment is needed to control the underlying dermatosis it may be necessary to continue with another corticosteroid preparation not containing nystatin and oxytetracycline. CHILDREN: children are more likely to develop local and systemic side effects and in general require shorter courses and less potent agents than adults; use the minimum amount that provides therapeutic benefit. In infants and children under 12 years, long-term continuous topical corticosteroid therapy should be avoided where possible as adrenal suppression can occur. ELDERLY: no difference in response identified, but decreased hepatic or renal function may delay elimination if systemic absorption occurs - use the minimum quantity for the shortest duration. RENAL/HEPATIC IMPAIRMENT: no numeric adjustment; where systemic absorption occurs (large surface area, prolonged use) metabolism and elimination may be delayed, increasing risk of systemic toxicity - use the minimum quantity for the shortest duration.