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Topical keratolytic + barrier

Salicylic acid with zinc oxide

A topical combination of salicylic acid with zinc oxide, formulated as a paste or paint used as a keratolytic and protective preparation, including for warts, corns and hyperkeratotic skin conditions.

Dosing — no UK product information found

We found no UK product information (SmPC) for this medicine or presentation on the eMC or MHRA Products (checked October 2026). It may be unlicensed in the UK, imported, a medical device, or no longer marketed. ClinCalc Pro shows only doses it can trace to official product information, so none is shown — follow your specialist service or local guideline.

Clinical monograph

How it works

Salicylic acid acts as a keratolytic, softening and removing thickened keratin, while zinc oxide provides a mild astringent and protective barrier action that soothes and shields the surrounding skin.

Prescribing in practice

  • Confine application to the affected lesion and protect adjacent healthy skin, as salicylic acid can cause irritation and erosion of normal skin.
  • Avoid use on the face, anogenital region, broken or inflamed skin, and on lesions in patients with diabetes or peripheral arterial disease without specialist advice.
  • The protective zinc oxide base may stain clothing and form an occlusive layer over the treated area.

Monitoring

No laboratory monitoring is required; review the treated lesion for response and excessive local irritation.

Counselling the patient

  • Pare or file down softened skin between applications and apply the paste to the lesion only.
  • Continue regular use over several weeks as directed.
  • Discontinue and seek advice if marked soreness, redness or skin breakdown occurs.

Evidence & guidelines

Salicylic acid is the established keratolytic active, with zinc oxide long used as a soothing, protective excipient in dermatological pastes.

Reference: Drug verified in RxNorm (NLM); confirm dosing against the manufacturer SPC (eMC). Verify against your local formulary and current prescribing references before prescribing. Monograph status: clinician-reviewed (2026-07-04).

Related

Curated clinical cross-links plus same-class fallbacks.

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