Retinoid + topical antibiotic
Tretinoin with clindamycin
Brand names: Treclin
Adult dose
Dose: Apply ON to affected skin
Route: Topical
Frequency: ON
Clinical pearls
- Mild-moderate acne
- Sun protection essential
Contraindications
- Pregnancy/breastfeeding
- Hypersensitivity
- Inflammatory bowel disease (clindamycin)
Side effects
- Skin irritation
- Photosensitivity
- Pseudomembranous colitis (rare)
Interactions
- Other photosensitisers
- Concurrent topical erythromycin/peroxide (cross-resistance)
Reference: BNF; NICE NG198; https://bnf.nice.org.uk/drugs/tretinoin-with-clindamycin/. Verify against your local formulary and the latest BNF before prescribing.
Related
Curated clinical cross-links plus same-class fallbacks.
Calculators
- Centor / McIsaac Score for Strep Pharyngitis · Throat
- FeverPAIN Score for Strep Throat · Throat
- Jarisch-Herxheimer Reaction Severity Assessment · Treatment Reactions
- PID Severity (CDC Diagnostic Criteria) · Gynaecological Infections
- FAST Exam Protocol — Focused Assessment with Sonography in Trauma · Trauma
- Gustilo-Anderson Classification (Open Fractures) · Fracture Classification
Pathways
- Suspicious Pigmented Lesion — Melanoma Pathway · NICE NG14 2015 / BAD
- Cellulitis and Erysipelas · NICE NG141 2019 / CREST
- Psoriasis — Severity Assessment and Step-Up Therapy · NICE NG153 2019 / BAD
- Atopic Eczema — Assessment and Step-Up Therapy · NICE NG95 2023
- Urticaria and Angioedema · BSACI / EAACI Guidelines 2022
- Acne Vulgaris — Grading and Treatment · NICE NG198 2021 / BAD