Anti-factor XIIa monoclonal antibody
Garadacimab
Brand names: Andembry
Adult dose
Dose: Loading 400mg SC; then 200mg SC monthly
Route: SC
Frequency: monthly
Clinical pearls
- Long-term prophylaxis of hereditary angioedema attacks (≥12 yrs)
- Specialist immunology
Contraindications
- Hypersensitivity
Side effects
- Injection site reactions
- Nasopharyngitis
- Headache
- Bleeding (rare)
Monitoring
- Attack frequency
- Bleeding risk if anticoagulated
Reference: BNF; NICE TA1041; SmPC; https://bnf.nice.org.uk/drugs/garadacimab/. Verify against your local formulary and the latest BNF before prescribing.
Related
Curated clinical cross-links plus same-class fallbacks.
Calculators
- Insulin Correction Factor (ICF/ISF) · Insulin Management
- R Factor for Drug-Induced Liver Injury (DILI) · Liver Disease
- Revised Original International Autoimmune Hepatitis Score (IAIHG) · Autoimmune Liver Disease
- Ho Index for Predicting Response to Medical Therapy in IBD · Inflammatory Bowel Disease
- Rh(D) Immune Globulin Dosage for Maternal-Fetal Haemorrhage · Haematology in Pregnancy
- SLEDAI-2K for SLE Disease Activity · SLE
Pathways
- New-Onset Atrial Fibrillation · ESC 2020 AF Guidelines; NICE NG196
- Hypertensive Emergency · ESC/ESH 2018 Hypertension Guidelines; NICE NG136
- Bradycardia Management · Resuscitation Council UK ABCDE; ESC 2021 Pacing Guidelines
- Ventricular Tachycardia / Fibrillation · Resuscitation Council UK ACLS; ESC 2022 Ventricular Arrhythmia Guidelines
- Syncope Assessment · ESC 2018 Syncope Guidelines; NICE NG109
- Acute Chest Pain · NICE CG95; ESC 2023 ACS Guidelines