Vitamin B3 (amide form)
Nicotinamide
Adult dose
Dose: Pellagra: 100–300mg/day in divided doses. Skin cancer chemoprevention (off-label): 500mg BD
Route: PO
Frequency: OD-divided
Clinical pearls
- Pellagra; non-melanoma skin cancer chemoprevention (ONTRAC trial; off-label)
- Does not cause flushing (unlike nicotinic acid)
Contraindications
- Hypersensitivity
Side effects
- GI upset
- Headache
- Hepatotoxicity (high dose, prolonged)
Reference: BNF; ONTRAC; https://bnf.nice.org.uk/drugs/nicotinamide/. Verify against your local formulary and the latest BNF before prescribing.
Related
Curated clinical cross-links plus same-class fallbacks.
Calculators
Pathways
- Diabetic Ketoacidosis (DKA) · JBDS 2013 / Joint British Diabetes Societies; NICE NG17
- Adult Hypoglycaemia (Treated Diabetes) · JBDS-IP (2023): Hospital Management of Hypoglycaemia
- Adrenal Crisis · Society for Endocrinology Emergency Guidance (2024)
- Type 2 Diabetes Management · NICE NG28 2022
- Hyperthyroidism Management · BTA / ETA 2018
- Adrenal Insufficiency · Society of Endocrinology / ESE 2016