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Long-acting parathyroid hormone (1-34) prodrug

Palopegteriparatide

Brand names: Yorvipath

Adult dose

Dose: Initial 18 micrograms SC OD; titrate per BNF/SmPC

Route: SC

Frequency: OD

Clinical pearls

Chronic hypoparathyroidism in adults; specialist endocrine

Contraindications

Pregnancy
Hypersensitivity

Side effects

Hypercalcaemia
Hypocalcaemia
Headache
Diarrhoea
Polyuria
Increased risk of osteosarcoma (theoretical)

Interactions

Calcium and active vitamin D — frequent dose adjustment as titrating

Monitoring

Serum calcium
Phosphate
24h urinary calcium
Renal function

Reference: BNF; SmPC; https://bnf.nice.org.uk/drugs/palopegteriparatide/. Verify against your local formulary and the latest BNF before prescribing.

Related

Curated clinical cross-links plus same-class fallbacks.

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