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Long-acting growth hormone analogue

Somapacitan

Brand names: Sogroya

Adult dose

Dose: Adult GH deficiency: 1.5mg SC once weekly initial, titrate per IGF-1
Route: SC
Frequency: weekly

Clinical pearls

  • Adult GH deficiency — once-weekly alternative to daily somatropin
  • Specialist endocrine

Contraindications

  • Active malignancy
  • Diabetic retinopathy (uncontrolled)
  • Acute critical illness
  • Pregnancy
  • Hypersensitivity

Side effects

  • Headache
  • Injection-site reactions
  • Peripheral oedema
  • Hyperglycaemia
  • Arthralgia
  • Carpal tunnel syndrome

Interactions

  • Insulin/oral antidiabetics
  • Corticosteroids (monitor cortisol)
  • Hormonal therapies

Monitoring

  • IGF-1
  • Glucose
  • TFTs
  • Adrenal function

Reference: BNF; NICE; SmPC; https://bnf.nice.org.uk/drugs/somapacitan/. Verify against your local formulary and the latest BNF before prescribing.

Related

Curated clinical cross-links plus same-class fallbacks.