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Intranasal corticosteroid + antihistamine

Fluticasone with azelastine

Brand names: Dymista

Adult dose

Dose: 1 spray each nostril BD
Route: Intranasal
Frequency: BD

Clinical pearls

  • Moderate-severe allergic rhinitis where mono-therapy inadequate
  • Onset within hours; faster than INCS alone

Contraindications

  • Hypersensitivity

Side effects

  • Epistaxis
  • Bitter taste
  • Headache
  • Nasal irritation

Interactions

  • Strong CYP3A4 inhibitors

Reference: BNF; BSACI rhinitis guideline; https://bnf.nice.org.uk/drugs/fluticasone-with-azelastine/. Verify against your local formulary and the latest BNF before prescribing.

Related

Curated clinical cross-links plus same-class fallbacks.